O papel da vitamina D na pandemia de COVID-19: revisão integrativa
Palavras-chave:
Covid-19. Vitamina D. Saúde Pública.
Resumo
A vitamina D tem sido muito discutida quanto a sua utilização em meio à pandemia de Covid-19 como tratamento de suporte. Neste sentido o presente trabalho teve como objetivo avaliar possíveis vantagens no uso da vitamina D, assim como avaliar sua eficácia e segurança como tratamento à Covid-19. Trata-se de uma revisão de literatura integrativa, utilizando as bases de dados: Biblioteca Virtual em Saúde (BVS), Pubmed e Cochrane Library. Os resultados obtidos não indicam que a suplementação de vitamina D possa prevenir ou tratar a Covid-19, apesar de resultados promissores. Portanto a vitamina D não tem eficácia comprovada para ser utilizada como tratamento ou mesmo profilaxia à Covid-19.
Referências
1. Brasil. Ministério da Saúde. Protocolo de Manejo Clínico do Coronavírus (Covid-19) na Atenção Primária à saúde. 2020;1–33.
2. Lana RM, Coelho FC, Da Costa Gomes MF, Cruz OG, Bastos LS, Villela DAM, et al. The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. Cad Saude Publica. 2020;36(3).
3. McCartney DM, Byrne DG. Optimisation of vitamin d status for enhanced immuno-protection against covid-19. Ir Med J. 2020;113(4):20–3.
4. Ribeiro H, Santana KV de S de, Oliver SL, Rondó PH de C, Mendes MM, Charlton K, et al. Does Vitamin D play a role in the management of Covid-19 in Brazil? Rev Saude Publica. 2020;54:53.
5. Hribar CA, Cobbold PH, Church FC. Potential role of vitamin d in the elderly to resist covid-19 and to slow progression of parkinson’s disease. Brain Sci. 2020;10(5):6–13.
6. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin d supplementation could reduce risk of influenza and covid-19 infections and deaths. Nutrients. 2020;12(4):1–19.
7. Zabetakis I, Lordan R, Norton C, Tsoupras A. Covid-19: The inflammation link and the role of nutrition in potential mitigation. Nutrients. 2020;12(5):1–28.
8. Meftahi GH, Jangravi Z, Sahraei H, Bahari Z. The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”. Inflamm Res [Internet]. 2020;(0123456789). Available at: https://doi.org/10.1007/s00011-020-01372-8
9. Iddir M, Brito A, Dingeo G, Del Campo SSF, Samouda H, La Frano MR, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the covid-19 crisis. Nutrients. 2020;12(6):1–39.
10. Lau FH, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo JD, et al. Vitamin D Insufficiency is Prevalent in Severe COVID-19. medRxiv. 2020;(504):1–14.
11. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence. medRxiv [Internet]. 13 de maio de 2020 [citado 21 de julho de 2020];2020.05.08.20095893. Available at: https://www.medrxiv.org/content/10.1101/2020.05.08.20095893v1
12. La Vignera S, Cannarella R, Condorelli RA, Torre F, Aversa A, Calogero AE. Sex-specific SARS-CoV2 mortality: Among hormone-modulated ace2 expression, risk of venous thromboembolism and hypovitaminosis D. Int J Mol Sci. 2020;21(8):5–10.
13. Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr Clin Res Rev. 1 de julho de 2020;14(4):561–5.
14. Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr [Internet]. 2020;74(6):856–9. Available at: http://dx.doi.org/10.1038/s41430-020-0661-0
15. Infusino F, Marazzato M, Mancone M, Fedele F, Mastroianni CM, Severino P, et al. Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: A scoping review. Nutrients. 2020;12(6):1–21.
16. Martín Giménez VM, Inserra F, Tajer CD, Mariani J, Ferder L, Reiter RJ, et al. Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. Vol. 254, Life Sciences. Elsevier Inc.; 2020. p. 117808.
17. Kakodkar P, Kaka N, Baig M. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus. 2020;2019(April).
18. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health [Internet]. 2020; Available at: https://doi.org/10.1016/j.jiph.2020.06.021
19. Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1). Journal of internal medicine. 2020. 0–2 p.
2. Lana RM, Coelho FC, Da Costa Gomes MF, Cruz OG, Bastos LS, Villela DAM, et al. The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance. Cad Saude Publica. 2020;36(3).
3. McCartney DM, Byrne DG. Optimisation of vitamin d status for enhanced immuno-protection against covid-19. Ir Med J. 2020;113(4):20–3.
4. Ribeiro H, Santana KV de S de, Oliver SL, Rondó PH de C, Mendes MM, Charlton K, et al. Does Vitamin D play a role in the management of Covid-19 in Brazil? Rev Saude Publica. 2020;54:53.
5. Hribar CA, Cobbold PH, Church FC. Potential role of vitamin d in the elderly to resist covid-19 and to slow progression of parkinson’s disease. Brain Sci. 2020;10(5):6–13.
6. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that vitamin d supplementation could reduce risk of influenza and covid-19 infections and deaths. Nutrients. 2020;12(4):1–19.
7. Zabetakis I, Lordan R, Norton C, Tsoupras A. Covid-19: The inflammation link and the role of nutrition in potential mitigation. Nutrients. 2020;12(5):1–28.
8. Meftahi GH, Jangravi Z, Sahraei H, Bahari Z. The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”. Inflamm Res [Internet]. 2020;(0123456789). Available at: https://doi.org/10.1007/s00011-020-01372-8
9. Iddir M, Brito A, Dingeo G, Del Campo SSF, Samouda H, La Frano MR, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the covid-19 crisis. Nutrients. 2020;12(6):1–39.
10. Lau FH, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo JD, et al. Vitamin D Insufficiency is Prevalent in Severe COVID-19. medRxiv. 2020;(504):1–14.
11. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence. medRxiv [Internet]. 13 de maio de 2020 [citado 21 de julho de 2020];2020.05.08.20095893. Available at: https://www.medrxiv.org/content/10.1101/2020.05.08.20095893v1
12. La Vignera S, Cannarella R, Condorelli RA, Torre F, Aversa A, Calogero AE. Sex-specific SARS-CoV2 mortality: Among hormone-modulated ace2 expression, risk of venous thromboembolism and hypovitaminosis D. Int J Mol Sci. 2020;21(8):5–10.
13. Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr Clin Res Rev. 1 de julho de 2020;14(4):561–5.
14. Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. Eur J Clin Nutr [Internet]. 2020;74(6):856–9. Available at: http://dx.doi.org/10.1038/s41430-020-0661-0
15. Infusino F, Marazzato M, Mancone M, Fedele F, Mastroianni CM, Severino P, et al. Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: A scoping review. Nutrients. 2020;12(6):1–21.
16. Martín Giménez VM, Inserra F, Tajer CD, Mariani J, Ferder L, Reiter RJ, et al. Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. Vol. 254, Life Sciences. Elsevier Inc.; 2020. p. 117808.
17. Kakodkar P, Kaka N, Baig M. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus. 2020;2019(April).
18. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health [Internet]. 2020; Available at: https://doi.org/10.1016/j.jiph.2020.06.021
19. Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1). Journal of internal medicine. 2020. 0–2 p.
Publicado
2021-04-09
Como Citar
1.
Lima J. O papel da vitamina D na pandemia de COVID-19: revisão integrativa. Revista de Saúde Pública do Paraná [Internet]. 9abr.2021 [citado 23dez.2024];3(2):169-78. Available from: http://revista.escoladesaude.pr.gov.br/index.php/rspp/article/view/406
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